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So far AllTrials has created 214 blog entries.

UN calls for global action on clinical trial transparency

In a landmark report released today, the United Nations called on governments worldwide to pass legislation requiring clinical trials to be registered, and their methods and results to be fully reported. The report, authored by a high-level panel appointed by UN Secretary General Ban Ki-moon, explicitly calls for clinical trial study designs, protocols, data sets, […]

14th September 2016|

Do sex hormones skew outcomes in clinical trials?

An essay published in Cell Metabolism in early August flagged the scarcity of female participants in clinical trials involving both humans and animals, arguing that men and women are biologically not the same and may therefore react to many drugs in different ways.

Deborah J. Clegg, a Professor of Biomedical Science at Cedars-Sinai Hospital in California who […]

31st August 2016|

Registering research made easy: the Research Registry explained

Over the past two years, Christopher Limb has been involved in the development and management of the Research Registry, a global platform for research registration designed and run by clinicians to meet the needs of the research community. In this guest blog, he explains how the Research Registry works and why it supports the AllTrials […]

31st August 2016|

Researchers who tested new medicines in over 69,000 children failed to publish results, new study finds

A new study published in the journal Pediatrics finds that clinical trials involving over 69,000 children have never had their results published in a peer reviewed journal, and that the findings of nearly a hundred of these trials remain completely unknown. The study, authored by Natalie Pica and Florence Bourgeois, both from Harvard medical school, examined all 599 pediatric trials registered with Clinicaltrials.gov […]

22nd August 2016|

How we dragged orlistat’s hidden “understated harms” into the light: An interview with Jeppe Schroll

A study published yesterday in the open access journal PLOS Medicine suggests that pharmaceutical companies often fail to tell doctors and patients the full story of the negative side effects of the drugs they sell. Comparing seven previously undisclosed clinical study reports from trials of the slimming drug orlistat (usually marketed as ‘Alli’) with publicly available […]

17th August 2016|

Trial reports “understated harms” of taking slimming drug orlistat (Alli), new study claims

A study released yesterday by researchers of the Nordic Cochrane Center suggests that pharmaceutical companies often fail to tell doctors and patients the full story of the negative side effects of the drugs they sell. Comparing seven previously undisclosed clinical study reports (CSRs) from trials of the slimming drug orlistat with publicly available information, the […]

17th August 2016|

Leaked pharma slide illustrates why investors care about clinical trial transparency

In an article published in The Street earlier this month, veteran biotech stock pundit Adam Feuerstein claims that “there are legitimate concerns about what Ionis discloses about the safety and tolerability of its antisense drugs in clinical trials”.

According to Feuerstein, the company in 2013
emailed copies of its newly updated corporate presentation to institutional […]

16th August 2016|

“Leading research entities routinely and flagrantly ignored their obligations to report trial results”

In December 2015, STAT published a widely discussed article and data set detailing how pharmaceutical companies and prestigious medical research institutions were routinely breaking the US legal requirement to publicly post clinical study results on ClinicalTrials.gov. In this interview, investigative journalist Charles Piller of STAT discusses how he and his colleagues extracted and analysed the […]

15th August 2016|

U.S. Senator Elizabeth Warren calls for clinical trial data sharing

Just months after U.S. Vice President Joe Biden threatened to cut funding to researchers who fail to report trial results, another political heavyweight in Washington D.C. has spoken out in favour of greater clinical trials transparency. Elizabeth Warren, a Senator from Massachusetts who frequently comments on lobbying and corruption issues, recently published an article titled […]

15th August 2016|

Chasing down a missing clinical trial result – a doctor’s odyssey

Note: The following is a guest blog by Dr Aus Alzaid, a practicing physician caring for people with diabetes in Saudi Arabia. Dr Alzaid can be contacted via LinkedIn. If you too have had problems accessing clinical trial results and would like to share your story, please contact the AllTrials team.

Many of my patients suffer […]

11th August 2016|