American Medical Association joins AllTrials

Today the American Medical Association (AMA) joins more than 641 patient advocacy groups, professional societies, medical organisations and thousands of patients worldwide in supporting the global campaign for clinical trial registration and reporting led by AllTrials.

AMA President, Steven J. Stack, said:
“The AMA strongly supports improving the timeliness and accessibility of clinical trial data to reduce the duplication of research […]

17th March 2016|

Lessons need to be learned from clinical trial tragedy

The British Journal of Clinical Pharmacology has published an editorial calling for improvements to the safety of clinical trials, following the tragic outcomes of the Bial clinical trial in January 2016, when five volunteers were hospitalised and one subsequently died.

The authors make several recommendations for learning from this tragedy, which include:

Pre-clinical and clinical study data from […]

16th March 2016|

Favourable results have more scientific impact than unfavourable results

A study published in JAMA Oncology has revealed that ‘positive’ cancer clinical trial results have a much higher scientific impact than ‘negative’ results.

A total of 94 patient studies were looked at, containing data from 46,424 trial participants. Out of these, only 28% of trials showed positive results. However, these trials were far more likely to be published in high impact journals than negative trials. […]

14th March 2016|

How institutions can audit registration and publication of clinical trials

In a world first, a clinical trial transparency audit of two major UK research institutions has been made publicly available. The study, published in BMJ Open, looked at the clinical trial registration and reporting performance of the Oxford Biomedical Research Centre (BRC), and the Oxford Musculoskeletal Biomedical Research Unit (BRU), who together received over £160m of public funds […]

9th March 2016|

Will the EMA’s guidance usher in a new era of trial transparency?

The European Medicines Agency (EMA) has published new guidance for pharmaceutical companies on how to comply with its policy on the publication of clinical data. The guidelines address how to prepare and submit clinical study reports (CSRs), including how to anonymise data, and how to identify and redact commercially confidential information.

CSRs are very long documents that contain detailed information about […]

9th March 2016|

Sense about Science is recruiting an AllTrials campaign manager

Campaigns manager

Sense about Science is an independent campaigning charity that monitors and challenges the misrepresentation of science and scientific evidence in public life. We advocate for openness and honesty about scientific claims and findings, and mobilise the public to ask questions about science and evidence.

We are recruiting for this post to run the AllTrials campaign […]

2nd March 2016|

Study finds poor clinical trial reporting from leading academic centres

A study published in The BMJ today has found staggeringly poor levels of clinical trial reporting from 51 leading academic medical centres in the USA.

The study looked at 4,347 studies that were completed between October 2007 and September 2010, and identified trials with missing results two years after the trial completion. For the 51 institutions, the proportion of trials published ranged […]

18th February 2016|

How is transparency going at the European Medicines Agency?

A new article published in Trials reports that the European Medicines Agency’s system of releasing clinical trial documents may involve lengthy correspondence, and significant time delays.

In 2010, the European Medicines Agency (EMA) introduced a new policy to make detailed clinical trial information available on request. Between 2011 and 2015, the authors of the Trial study made 12 separate requests […]

16th February 2016|

MEPs call for faster implementation of clinical trial regulation

The Group of the Progressive Alliance of Socialists and Democrats (the S&D Group) is today calling on the European Commission to speed up implementation of the new European Clinical Trial Regulation. The S&D Group is the second largest political group in the European Parliament with 190 members from all 28 EU member states.

The call follows the recent […]

2nd February 2016|

Wellcome Trust appoints new independent review panel for clinical data sharing website

The Wellcome Trust has appointed a new independent review panel to assess applications from researchers for access to clinical trial data through the website

The website was set up by GlaxoSmithKline (GSK) in May 2013 to allow researchers to request trial data to carry out further research. Since then 12 more pharmaceutical companies have also committed to […]

26th January 2016|