AllTrials: Make clinical trials count

Thousands of clinical trials have not reported their results; some have not even been registered. Information on what was done and what was found in these trials could be lost forever to doctors and researchers, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated. The contributions of the hundreds of thousands of patients who took part in those trials remain unused and unusable.

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AllTrials: Withholding results costs lives

The results of a 1980 clinical trial on heart drug Lorcainide were not published until a decade later. Doctors didn’t know that more people died in the trial who were given Lorcainide than who were taking the placebo. It has been estimated that over 100,000 people died avoidably because they were prescribed drugs in the same class. Read about how the researchers were able to get the results of the study published.

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AllTrials: Doctors are being misled

Dr Ben Goldacre prescribed the antidepressant Reboxetine for a patient but says he was “misled.” Results from trials which showed it was worse than other drugs were withheld, while the smaller number of trials which showed it worked better were published.

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AllTrials: Medicine is broken

The UK Government has spent £424 million stockpiling Tamiflu, an anti-flu treatment, but we still don’t know if this treatment works any better than placebo. Regulators weren’t given information from all the clinical trials done on Tamiflu. The manufacturers of Tamiflu didn’t break any laws by withholding the information.

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Why clinical trial transparency matters to patients in the US

Why patients and patient advocates like AnneMarie Ciccarella and Gregg Gonsalves support AllTrials, to get all clinical trials registered, and their results reported.

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A background to clinical trials

A short, clear, engaging animation that explains clinical trials, created by the European Communication on Research Awareness Needs ECRAN project. The video has been translated into 22 languages.

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