Latest Campaign Updates

Clinical trial publishing game, from The Economist

The results of around half of all clinical trials have never been published. Failing to publish results means the people who make decisions about medicines don’t have full information about the benefits and risks of treatments we use every day.

Use The Economist’s publication bias simulator to run clinical trials yourself, decide which trials to publish, and see how much […]

6th October 2015|

Cipher machine used to hide secrets will be auctioned to help reveal medical secrets

We are delighted that Simon Singh, science writer and Sense About Science trustee, is auctioning his Second World War cipher machine to raise money for the AllTrials campaign and Good Thinking.

The M-209 is a portable mechanical cipher machine (about the size of a lunchbox) that was used by the US military during WW2 and the […]

1st October 2015|

Plastic Surgeons join AllTrials and call on next generation of surgeons to support the campaign

The British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS) has joined AllTrials and is calling on the next generation of surgeons to support the campaign.  BAPRAS and the Reconstructive Surgery Trials Network (RSTN) have committed to register all trials they’re involved with and will report results within one year of trial completion. BAPRAS has also […]

18th September 2015|

New research on old data

Many supporters of AllTrials will be interested in a study published in The BMJ today, a reanalysis of previously hidden clinical trial data. The new research used data from a 1990s clinical trial of the GlaxoSmithKline (GSK) antidepressant drug paroxetine. Today’s findings contradict a 14-year-old analysis of the data referred to as Study 329, which found paroxetine to be safe and […]

17th September 2015|

UK autism research charity make strong commitment to trials transparency

Autistica, a UK charity that has raised over £8.5 million in support of autism research has pledged its support for trials transparency by joining AllTrials and adopting the principles of the campaign as part of its grant awards process.

On joining the campaign, Autistica said:
“Autistica is a vital bridge between a diverse autism community and medical […]

10th September 2015|

WHO calls for data sharing “by default” in public health emergencies

The World Health Organization (WHO) has said that clinical and epidemiologic data should be made openly available, as close to real-time as possible, during public health emergencies.

In Geneva yesterday, representatives from Government, public health agencies, scientists, research funders, ethicists and industry met to discuss data sharing in light of the recent Ebola crisis. Participants agreed […]

3rd September 2015|

‘Good Publication Practice’ guidelines call for all clinical trials to be reported

Updated Good Publication Practice (GPP3) guidelines have been published in the Annals of Internal Medicine. The updated guidelines include a new section on data sharing, and continue to call for all clinical trials to be reported in a complete, accurate, balanced, transparent, and timely manner.

The guidelines are designed to help individuals and organisations maintain ethical and legal […]

28th August 2015|

Systematic review makes good use of unpublished trial data

A systematic review on beta-blockers for high blood pressure has for the first time used data from two large clinical trials that were previously unavailable. The review from the Cochrane Collaboration analysed data from eight clinical trials that included nearly 1500 patients who had been treated with either carvedilol or labetalol. The two largest trials […]

27th August 2015|

AllTrials and EMIG open letter to the HRA – Reply

Last week, AllTrials and the Ethical Medicines Industry Group wrote to the Health Research Authority (HRA), to let them know that AllTrials supporters, the UK biopharmaceutical industry, and the English Courts support their continued work on clinical trials transparency.  Today, the HRA published a responding letter from Dr Janet Wisely, CEO of the HRA, alongside a statement in relation […]

25th August 2015|

Registration not being enforced by psychiatry journals

A new study in PLOS ONE found that, despite International Committee of Medical Journal Editors (ICMJE) guidelines, only one third of clinical trials published in the five most influential psychiatry journals were correctly registered before patient enrolment. In 2005, the ICMJE introduced the prospective registration guidelines, which led to many journals making prospective registration a condition for publication.

Looking at […]

21st August 2015|