With the World Health Organisation’s recent Statement on Public Disclosure of Clinical Trials Results, affirming that researchers have an ethical imperative to make results from all clinical trials publicly available, it is clear that we have made remarkable progress on the call for greater clinical trial transparency. However, as we have seen before, recognition of […]
In the latest issue of the Bulletin of The Royal College of Surgeons of England, surgeons who have run clinical trials say “surgeons have a professional and ethical duty to ensure trial results are made available.” The surgeons point out that previous efforts to make registration and reporting of clinical trials a requirement, like the […]
Jeppe Schroll and Lisa Bero argue in an editorial in the Cochrane Library that clinical trial information from regulators should be included in systematic reviews of treatments. In 2014, they showed that drug reports from the European Medicines Agency (EMA) and the US Food and Drug Agency (FDA) contained enough information to be used in […]
A new strong and detailed report, written by Nordic clinical trial experts, sets a high international standard for clinical trial transparency and sets out how to make it a reality. The report from the Nordic Trial Alliance Working Group on Transparency and Registration aims to make the Nordic countries world leaders in clinical trial transparency. […]
The World Health Organisation (WHO) made it unambiguously clear today that researchers have an ethical imperative to make results from all clinical trials – including past trials – publicly available. Its Statement on Public Disclosure of Clinical Trials Results:
says results from clinical trials should be publicly reported within 12 months of the trial’s end,
calls for results […]
Health Canada is seeking comments on new regulations that will determine what information from clinical trials will be made public and when. In June 2014, the Canadian Government passed Bill C-17 or “Vanessa’s Law”. After many of you wrote to Canadian MPs on the Health Committee, the law was amended so that some trial information would […]
A new study in JAMA Internal Medicine has found that clinical trials on treatments for cardiovascular diseases that were registered were less likely to report positive results than unregistered trials. Researchers looked at clinical trials that were published on PubMed in December 2012 and found 191 on cardiovascular diseases, 45% of which had been registered. […]
This is a guest post by Ella Flemyng and Daniel Shanahan of BioMed Central, which is a supporter of the AllTrials campaign.
Clinical trials are one of our most valuable types of research for identifying cause-and-effect in healthcare interventions. However, while ‘positive’ results—those that support carefully-constructed hypotheses—often get the most attention, non-confirmatory or so-called ‘negative’ results […]
This is a guest post by Jennifer Horsley, PLOS Collections, Meghan Byrne, PLOS ONE and Sarah Wade, PLOS ONE. PLOS is a co-founding organisation of AllTrials.
The publication of negative results is vitally important for many reasons, not least that it helps prevent duplication of research effort and potentially expedites the process of finding positive results. […]
A new study in the New England Journal of Medicine (NEJM) found that, despite being required to do so by law, most clinical trials aren’t reported within a year of completion. Under the FDA Amendment Act 2007 (FDAAA), most clinical trials in the US on treatments approved by the FDA have to publicly report their […]