An initiative of
The AllTrials petition has been signed by 458 organisations
AllTrials petition has been signed by 458 organisations
Comments from organisations
Medical Research Council: The MRC is pleased to sign up to this campaign and has, for many years, strongly supported the position that clinical trial results must be published in a timely manner. At the end of 2012, we made both the requirement to publish, and the need for MRC-funded researchers to share data, even more explicit: “results of MRC-funded clinical studies (whether positive or negative) must be published within a reasonable period (generally within a year of completion) following the conclusion of the study. Results should be reported in accordance with the recommendations in the CONSORT statement [Schulz et al. BMJ 2010; 340: c332]. Data should be made available in line with the MRC Policy on Data Sharing” The MRC celebrates its centenary this year and it would be surprising if, in our one hundred year history, there were no unreported or unpublished skeletons in our cupboards. However, tools such as e-Val (developed by the MRC and the precursor of ResearchFish) and Gateway to Research will mean funders such as ourselves will find it far easier to monitor adherence to the policy.
Wellcome Trust is pleased to sign this petition. We support full and unrestricted access to the outputs of research, including clinical trials, and consider this to be a key component of the research pathway and of our vision to achieve extraordinary achievements in human and animal health. The full statement is available here
NICE: We strongly believe that all clinical trial data should be made available so that those with responsibility for developing guidance and making treatment decisions have all the necessary information to hand to help them do so safely and efficiently.
Health Research Authority and National Research Ethics Service, now part of the HRA, have long endorsed the registration of research and subsequent publication of research results. We are delighted to sign up to the petition, which is entirely consistent with our remit to protect and promote the interests of patients and the public in health research.
German Institute for Quality and Efficiency in Health Care: IQWiG supports the campaign for all trials to be registered and the full methods and the results to be reported. IQWiG prepares health technology assessments to support decision making in the German health care system. During the past years we have experienced that full availability of all clinical trials and all information on methods and results of these trials is essential for us to provide unbiased and meaningful assessments. Health technology assessment should be based on a full evidence base and thus requires registration and reporting of all trials, regardless of whether they are conducted by industry, academia, governmental organisations or others.
South African Medical Research Council: The vision of the SA MRC is to build a healthy nation through research. Unregistered clinical trials and unpublished, inaccessible results of research pose a barrier to achieving this vision. The SA MRC has long supported the importance of minimising publication bias. We provide a home for the Pan African Clinical Trials Registry (www.pactr.org), a WHO recognised register which has specific capability to serve researchers, decision makers and patients in Africa. We are pleased to add our signature to this AllTrials petition and support the call for open access to the results of all clinical trials.
GSK: We are pleased to sign up to the AllTrials campaign for clinical trial transparency and support its call for the registration of clinical trials and the disclosure of clinical trial results and clinical study reports (CSRs). The full statement is available here
British Medical Association is pleased to sign the AllTrials petition. Doctors need accurate and unbiased information on the efficacy and safety of different treatments to help them prescribe properly, safely and most effectively for their patients. If data from clinical trials are withheld or otherwise not available, doctors cannot be sure of the risks and benefits of using particular drugs thus risking avoidable harm to patients and wasting scarce NHS resources. The full statement is available here
Royal Society of Medicine: As an organisation whose mission is concerned with providing education for healthcare professionals, the Royal Society of Medicine strongly supports the concept that the results of all clinical studies should be placed in the public domain. Without this, patients run the very serious risk of receiving suboptimal clinical care.
Royal Statistical Society is committed to transparency in scientific and social research. It is crucially important that the results of scientific research be made publicly available and disseminated as widely as is practical, in a timely fashion. Decisions to publish should not be based on whether research findings are ‘positive’ or ‘negative’.
Royal College of Pathologists: Openness and transparency are essential in research so that patients, policy makers and health professionals can make decisions vital to health care based on sound evidence. Pathologists are in the vanguard of healthcare research, especially in the area of precision diagnostics, the basis of personalised medicine. The Royal College of Pathologists is pleased to be able to support this important campaign.
Royal College of Paediatrics and Child Health: Over the last few years public confidence in some of our great institutions has been damaged by a series of scandals and cover-ups and this has created an even more profound obligation on all of us working in the healthcare sector to be as transparent and open about the work we do. The pharmaceutical industry has and will continue to have a central role in developing effective products for licence as medicines but to maintain the trust of the public it has to do so on the basis of full publication of research trials so that any decisions to licence or use them can be made fully informed of all the evidence.
Royal College of Physicians of Edinburgh has long supported the concept of evidence-based medicine through our founding and support for the Scottish Intercollegiate Guidelines Network (SIGN) and our links with the Cochrane Collaboration and James Lind Initiative. The College commends the objectives of the petition to call for greater transparency in the reporting of methodology and results from all clinical trials.
Royal College of Obstetricians and Gynaecologists encourages the study and advancement of the science and practice of obstetrics and gynaecology. We do this through postgraduate medical education and training development, and the publication of clinical guidelines and reports on aspects of the specialty and service provision. The RCOG Global Health Office works with other international organisations to help lower maternal morbidity and mortality in under-resourced countries. To fulfil this role, the College promotes study and research into obstetrics and gynaecology and publishes the results. The RCOG is happy to champion the All Trials enterprise which can only increase awareness about clinical trials.
Faculty of Pharmaceutical Medicine has signed up to the AllTrials campaign as we believe that the increased scrutiny of clinical trial results and data will lead to enhanced and more rigorous science, and ultimately better health outcomes for patients. The Faculty has shown a longstanding commitment to the publication and dissemination of trial data through our ‘Guiding Principles for Pharmaceutical Physicians’, and we see the aims of the AllTrials campaign as being closely aligned to this commitment.
Faculty of Public Health has over 3,300 members, all of whom are trained to find evidence-based solutions to complex problems. We strongly support AllTrials’ call for all trials to be reported and scientific data to be more fully in the public domain. Previous cases of suppressed evidence include the links between some SSRI antidepressants and suicide, as well as research into COX2 inhibitors and cardiac failure. These show us how vital it is that all research data is available in the public domain so that we can protect the public from harmful side effects of drugs. When making potentially life or death decisions about people’s health, our members need access to all the relevant data, not just the information people may choose to publish.
Cochrane Collaboration strives to produce high quality, timely systematic reviews to help patients, clinicians and others make decisions based on the best available evidence. The success of these endeavours is seriously weakened if those preparing reviews cannot access all the relevant information. When data are missing, this poses a real threat to patients. The risks and benefits of treatments cannot be properly evaluated in an unbiased way. It is vital that all clinical trials are registered and all results reported, regardless of what those results are.
COPE supports the AllTrials initiative for all trials to be registered and all results reported. Publication ethics is not just about such issues as prevention of plagiarism and managing conflicts of interest, but is, more widely, about ensuring the integrity of the scholarly literature. Registration of trials and full reporting of results is a critical step in counteracting the bias towards positive results in the medical literature.
World Association of Medical Editors seeks to promote the highest standards in conducting, reporting, and disseminating medical research in the service of improving personal and public health worldwide. To this end, WAME lends its full support to the AllTrials initiative, extending WAME’s policy that all clinical trials should be registered (http://www.wame.org/
PLOS strongly endorses Alltrials’ call for all trials to be registered and reported. It not only resonates with our core values but, moreover, at PLOS we provide specific, concrete ways that the call can be turned into action. As an open access publisher, PLOS was founded on the principle of increasing the availability of both papers reporting studies and the underlying data associated with studies and as has strong policies on data availability. From the very beginning of medical publishing at PLOS, in PLOS Medicine in 2004, we have always insisted on the prospective registration of trials and that protocols for clinical trials are submitted with the trial paper and published alongside it. In addition, we have a specific commitment to publishing the results of so-called negative trials, particularly in our journal PLOS ONE, which does not select papers on impact, but only on objective measures such as whether the work is done to high scientific and ethical standards, whether the work is appropriately described, and whether the data support the conclusions.We therefore welcome this new initiative and call on other publishers and medical journals to develop ways to make universal registration and reporting a reality, rather than just an aspiration.
British Library: Enabling access to everyone who wants to do research is a key aim for the British Library. We therefore support initiatives that enable people to have access to the evidence and make informed decisions, as a result.
Global Health Information Network, which administers HIFA2015 and other HIFA Global Forums, supports the AllTrials proposal that ‘All trials past and present should be registered, and the full methods and the results reported’. Full transparency is necessary to ensure that health professionals have access to the best possible evidence on which to base their decisions. Adequate support should be provided for research in low-income countries to ensure that trial data are robust and readily available
British Pharmacological Society today announces its intention to sign the All Trials petition, www.alltrials.net. This decision underlines the Society’s unqualified commitment to the principles of transparency in clinical trials, which has been a central theme of its collaborative work with organisations in health and commercial life science settings for a number of years. The full statement is available here
Royal Pharmaceutical Society: The English, Welsh and Scottish Boards have announced today a commitment to increased clinical trial transparency through active membership of the AllTrials campaign. The full statement is available here
BioMed Central: Publication bias is a serious problem in medical research and increasing transparency in clinical trials reporting is important. Open access publishing and public registration of trials offer the tools to help improve the reliability of medical evidence. All BioMed Central’s medical journals require prospective registration of clinical trials as a condition of publication, and we operate the ISRCTN register, one of the world’s largest trial registration databases. Many of our journals, including Trials journal, actively encourage the publishing of all research results, positive and negative, in addition to trial protocols. The AllTrials campaign comes at a time when there is much needed attention on the problems of reliability in medical research and we are looking forward to working with the campaign and like-minded organizations to leverage this momentum for the benefit of science and, ultimately, patient care.
Association of Medical Research Charities support the registration of clinical trials and the publication of findings. The full statement is available here
Patients Involved in NICE is pleased to support the AllTrials campaign to ensure the full details of all clinical trials, past and present, are reported and made available to regulators and clinicians. The full statement is available here
Drug and Therapeutics Bulletin supports the campaign for all trials to be registered and for all results to be reported. DTB believes that the availability of such data is essential to ensure that medicines are used safely and effectively. With very few exceptions, DTB only uses source material that is published (or, very occasionally, ‘in press’). We closely ally ourselves with our readers and so only use data in the public domain. In this way, the basis for the conclusions is available to our readers for independent assessment.
GIMBE Foundation strongly supports the AllTrials initiative for three reasons. First, 21 years after the birth of the EBM it is now time for a true (and not a selectively published) evidence base to inform all professional, managerial and political decisions. Secondly, the selective or missed publication of trials clearly breaks the pact with participants, that through informed consent accept to join the trial to improve knowledge about treatments’ effects on specific conditions. Last, but not least, under-reporting of research leads to a waste of money, as unpublished results will never lead to public health improvements. By ensuring that all trials will be registered and all results will be published, the investments in clinical research will finally turn into real benefits for citizens’ health.
Open Knowledge Foundation strongly endorses the All Trials campaign. We believe that this kind of essential information about the world should be free for everyone to access, scrutinise and share.
American Medical Student Association strongly endorses the AllTrials Campaign to make available all clinical trial results for all treatments being currently used. For over a decade, AMSA has been advocating for medical education and practice that is evidence-based, rather than marketing based. Evidence-based medicine, however, is not possible with the continued allowance of pharmaceutical and device industries to hold hostage key clinical trials that may impact a prescriber’s decision-making ability. AMSA signs onto the AllTrials petition as a crucial step to ensure that the lives of our patients and the integrity of our profession are protected.
Center for Information and Study on Clinical Research Participation has long supported transparency and its critical role in engaging all stakeholders in the clinical research enterprise. This important initiative is a crucial step in helping to restore public trust and supports CISCRP’s mission to communicate clinical trial results to all volunteers who give the gift of their participation to advance medical knowledge.
UK Research Integrity Office supports the AllTrials petition. We have always stressed – through our practical advisory service, our education and training, and our publications – that all research should be conducted to the highest standards of honesty, accuracy, integrity and accountability. The full statement is available here
Association of Research Ethics Committees is an independent, self-governing body of Research Ethics Committees, local and multi-centre, including their members and administrators. AREC supports the AllTrials initiative for all trials to be registered and all results reported. Research ethics includes ensuring that studies involving human beings are published and all results, positive and negative, disseminated.
UK Clinical Pharmacy Association: Clinical pharmacists, like other healthcare professionals, rely on the transparent reporting of clinical trial data in order to achieve the best possible outcomes for patients. This aim cannot be achieved if the published evidence base is incomplete or inaccessible. The United Kingdom Clinical Pharmacy Association believes that the call to publish all available trial data is a simple call to fulfill an obvious moral obligation
Macmillan Cancer Support: If patients are to be offered the right care, all information about drug trials should be published and available for scrutiny, not just the data which presents a new treatment in the most favourable light. This is currently not happening, and people have been unnecessarily harmed because of it. It is particularly important for cancer patients, as a large proportion of new drugs in the pipeline are cancer drugs.
Cancer Research UK is pleased to sign up to the All Trials campaign, and we welcome the public discussion on how to increase transparency in clinical studies. The full statement is available here
Cavernoma Alliance UK and its entire membership wholeheartedly endorse this campaign. For all medical condions, it is essential that the results of clinical trials are made available. And, to that end, the All Trials Campaign must be successful.
Teenage Cancer Trust would welcome measures to bring more transparency to clinical trials.
Marie Curie Cancer Care is pleased to sign the AllTrials petition calling for greater transparency in clinical trials. Publicly available trial results, whether positive or negative, will lead to better clinical decisions and better quality of care. This closely aligns with the charity’s aim of putting patients and families first.
Irish Cancer Society: We are absolute in our belief that all clinical research data be published in order that people who get cancer, or any other medical condition, will have better access to improvements in the diagnosis and treatment of their condition which will lead to better medical care and better outcomes. Cancer patients lives are dependent on this.
Cancer52 supports the AllTrials petition calling for all clinical trials to be registered and results to be published because people with rare and less common cancers need access to clinical trials and new treatments. To deliver on this we need to see the results, good or bad, of trials that have gone before.
British Heart Foundation is the nation’s heart charity, dedicated to saving lives through pioneering research, patient care, campaigning for change and by providing vital information. We are pleased to support the AllTrials initiative and its efforts to increase transparency in clinical trials. As a major funder of heart disease clinical studies, including ground-breaking work like the Heart Protection Study, we recognise the need to ensure patients and clinicians have confidence in the outcome of clinical trials. We have established our position in our response to the Science and Technology Select Committee’s inquiry on clinical trials. To find out more about our life-saving research funding visit bhf.org.uk/science.
HealthWatch is a UK charity which was registered in 1991 to promote evidence-based medicine, quality information about health, and fair tests of health treatments. These principles save lives. Biased information resulting from selective publication of data has resulted in thousands of unnecessary deaths. Furthermore, non-publication of data is a violation of the informed consent process in which patients agree to take part in research believing it to be for the advancement of medical science. Those responsible for making healthcare decisions need to have at their disposal all possible evidence, which means they need ready access to all data resulting from fair tests of treatments. For these reasons HealthWatch is pleased to add its support to the AllTrials campaign.
European Federation of Clinical Chemistry and Laboratory Medicine represents the National Societies practising Laboratory Medicine in Europe, a specialty said to contribute in up to 70% of medical cases. Thus we affirm that adherence to ethical standards and the dissemination of all scientific data to inform clinical decision making is axiomatic for the provision of the quality health care that patients expect; EFLM fully supports the tenets of Evidence Based Medicine.
European Public Health Association, representing over 14,000 public health professionals across Europe, is committed to the highest standards in the conduct and reporting of research. We endorse the view that all trial protocols and data are made publicly available for independent and critical appraisal.
Swedish College of General Practice strongly endorses this campaign. SFAM promotes professional education, research and development in general practice. We work for the practice of evidence based medicine and for rational pharmacotherapy in cooperation with our patients. To achieve this, we regard it as fundamental that all trial protocols and results without exceptions are made publicly available for independent and critical appraisal.
NEPI Foundation, a non-profit organization established by the Swedish Parliament in order to facilitate the development of pharmacoepidemiology, supports the AllTrials initiative since openness and transparency with regards to research results constitute a foundation for comparative-effectiveness research. The practice of evidence-based medicine is not possible if research groups and companies can withhold results from scrutiny by the research community.
Netherlands Epidemiological Society fully supports the AllTrials initiative and is therefore pleased to sign this petition. Access to results, especially from clinical trials, is needed to reach unbiased conclusions.
Asociación Española de Pediatría de Atención Primaria: AEPap https://www.aepap.org/ representing more than 3000 pediatricians across Spain, is proud to endorse the AllTrials campaign. We are committed to transparency in research so that the best treatments for children can be developed and evaluated, and it is vital that all clinical trials are registered and the results reported.
Muscular Dystrophy Campaign is pleased to support the AllTrials petition calling for all clinical trials to be registered and results to be published. The full statement is available here
London School of Hygiene & Tropical Medicine supports full open access to the results of research, including clinical trials. The full statement is available here
Leukaemia CARE is pleased to sign this petition backing the AllTrials campaign. We fully support unrestricted access to the results and outcomes of all clinical trials; calling for the registration, disclosure and transparency of all clinical research (clinical study reports and clinical trials) regardless of whether the results are negative or positive.
Norwegian Cancer Society whole-heartedly supports this petition. As a big funder of research, we would like the money to be put to good use. We believe in sharing and documenting results to better advance the research. We believe that easy access to previous research in a timely manner will help the researchers help patients get better treatments quicker. We strongly support the sharing of methodology and results.
Parkinsons UK: We believe that the results of every Parkinson’s trial should be made public regardless of the findings. That’s why we’ve signed up to support the All Trials Registered, All Results Reported campaign. We’re also working closely with other research charities to make sure that new rules being developed to govern clinical trials across Europe – the EU Clinical Trials Regulation – make reporting results mandatory.
Brain Tumour Charity supports the AllTrials petition calling for all clinical trials to be registered and results to be published. We believe that this is necessary to ensure that potential new treatments move into clinical trials and the clinic as quickly as possible and that patients obtain the most benefit from the results of previous trials.
eLife enthusiastically supports AllTrials’ call for all clinical trials to be registered and reported. The last decade has seen a revolution in open-access publishing of scientific articles to audiences as wide as possible. eLife is dedicated to advancing scientific excellence and also access to the best science. In this spirit, AllTrials’ efforts to ensure full reporting of clinical trials are consistent with the goals of eLife. Rapid review processes, fair scientific scrutiny by scientists and the use of additional web-based materials and open-access methods ensures that eLife is well placed to meet AllTrials related objective of fast and fair publication of key clinical trial results. We therefore welcome AllTrials and call on other journals to support this important new initiative.
Stop AIDS Campaign exists to provide universal access to effective HIV prevention, treatment, care and support. We believe in evidence-based medicine and full access to information to ensure better health outcomes for patients globally. We are therefore pleased to endorse the AllTrials Campaign which aims to ensure full transparency in clinical trial data, enabling informed decision-making and ultimately major improvements in global health.
UK Sepsis Trust is a registered charity representing the interests of patients with sepsis and their relatives. Sepsis is a complex, deadly and diverse condition which presents in many ways and to many areas of healthcare. This diversity brings a need to bring together all robust data on sepsis identification and management in order that our expert clinicians and patient advisors may work to design the best patient care systems. We welcome and fully support the AllTrials campaign.
Bone Cancer Research Trust supports the AllTrials Campaign in their call to see all clinical trial results published and made available to the medical research community and the public.
Stroke Association are pleased to sign the AllTrials petition. We are committed to transparency in research so that the best treatments can be developed and evaluated, and it is vital that all clinical trials are registered and the results reported.
SABRE Research UK strongly supports the AllTrials Campaign. We go further and call for all trials (clinical and pre-clinical) to be registered and reported. All results (processed and raw with sensitive patient data protected) need to be published in full and with open access. Failure to do so is causing harm to patients and wastes funding. Research is unethical for the participants of clinical research and subjects of laboratory research whenever a trial is not registered and not reported.
Evidence-Based Veterinary Medicine Association is proud to endorse the All Trials campaign. Transparency and accessibility of clinical trial data for all stakeholders is as critical in veterinary medicine as in human medicine. The EBVMA supports the creation of an independent registry for veterinary clinical trials and encourages registration and full reporting of all clinical trials in both human and veterinary medicine. We support an open access publishing model, publication of all trial results whether positive or negative, adherence to high quality reporting standards such as exemplified by the CONSORT and REFLECT statements, and full registration and reporting of clinical trials because these practices are necessary for the effective practice of evidence-based medicine and the highest quality of patient care.
British Society for Gene and Cell Therapy is very happy to support the All Trials campaign. As a society, we strongly believe that the publication of all clinical trials data is critical if we are to accelerate the development of effective, evidence-based treatments for patients. Restricted access to clinical data slows progress and hampers the efforts of research scientists and healthcare professionals. All clinical trials should be registered and the results, whether negative or positive, be made available to researchers and clinicians.
British Society for Immunology wholeheartedly supports the AllTrials campaign. It is essential that all clinical trials are registered and that methodologies and results are placed in the public domain where they are freely available to all. This will support research efforts and ultimately lead to improved clinical treatment programmes.
Renal Association is pleased to support this important initiative to ensure that patients and doctors decisions are based on the best evidence.
Rett Syndrome Research Trust works to accelerate treatment for Rett Syndrome and related MECP2 Disorders. We are pleased to support the AllTrials petition calling for all clinical trials to be registered and results to be published, in order to ensure that potential new treatments can move into clinical trials as quickly as possible.
Depression Alliance: We at DA are pleased to support to the AllTrials campaign. Lack of information about depression, followed by lack of choice in treatments are constant ongoing concerns for our members in being able to maintain recovery. We are signing this petition to improve people’s access to information and support them in making choices over the treatment offered.
Scientists for Labour is happy to support the AllTrials campaign. Retrospective registration of clinical trials is important for future generations of researchers to build on the successes and failures of the past. Full disclosure of outcomes is also vital for governments trying to make evidence based, economically sound decisions on what treatments are made available to populations. SfL will work to promote AllTrials within the Labour Party in the UK and Europe.
SAGE was founded as, and remains, an independent publisher committed to the goal of disseminating usable knowledge that lies at the heart of a healthy society. We publish a range of medical journals, many in association with some of the world’s most prestigious societies, and offer a broad spectrum of options, both open access and traditional, for rapid publication of clinical trials results, welcoming both ‘positive’ and ‘negative’ results. We strongly support the call for all clinical trials to be registered and for the full results to be reported in a timely fashion.
PhUSE is committed to transparency in clinical trial reporting. It is important that the results of all scientific research be made publicly available and disseminated as widely as is practical, in a timely fashion.
Radical Statistics is delighted to support the AllTrials movement to make clinical trial research open and scrutable to the public.
DXY: As the biggest online community for healthcare professionals in China, DXY is devoted to better communication and better quality within the healthcare industry. All clinical trials should be compulsorily registered, and all the individual data should be open for public scrutiny. DXY spares no effort to reveal the truth and propagate its importance and potential benefits to patients, physicians, researchers, and regulators in China.
MedScii signs the petition and strongly endorses AllTrials’ call for all trials to be registered and reported. As the leading academic service provider in China, MedSci offer specific and professional ways that the call can be turned into action. We signed this because we believe that the more comprehensive the data the more effective the healthcare. Science should not be done in secret.
The Lupus Research Institute and our New York affiliate, the SLE Lupus Foundation, are pleased to support the AllTrials petition for transparency in clinical trials. The LRI is the leading private funder of novel research in the autoimmune disease systemic lupus erythematosus and a strong advocate for patient participation in clinical trials. With a desperate need for new treatments for lupus and insufficient enrollment in clinical trials testing new drugs, access to trials results is extremely important for our community.
Birth Trauma Association signed this because we strongly believe that good maternity practice should be based on good, strong evidence, no ideology or anecdote. Without transparency and openness, this is not possible.
National Collaborating Centre for Mental Health, as guideline developers for NICE, are pleased to sign this petition and to support the AllTrials campaign. Access to all trial results will improve guideline recommendations and lead to better quality of care
UK Cystic Fibrosis Gene Therapy Consortium supports this campaign whole heartedly. All clinical trials should be registered and results published. “Negative” outcomes have as much scientific value as “positive” outcomes and publication of all data is necessary to progress translational research as quickly and safely as possible.
Autism Rights Group Highland: We are signing because we believe that transparency and honesty are essential to progress and should be embedded within every stage of research to ensure that no trial is ever hidden, whatever the results.
Beating Bowel Cancer: Patients need as much information as possible when dealing with their disease. We believe that transparency and openness can only lead to better outcomes for patients.
Research Autism: As the only UK charity exclusively dedicated to research into interventions in autism we firmly believe that all clinical trial data should be made freely available. Publicly available trial results, whether positive or negative, will lead to better clinical decisions and better quality of care.
Throat Cancer Foundation support AllTrials because we believe that only by sharing and seeing all data can we truly feel the benefit of research. Withholding data and obscuring results can only ultimately slow down or halt progress and we are delighted to support AllTrials in their efforts to ensure transparency.
Balance: As a health institution and family planning center, we are shocked to learn that about half of all clinical trials have never been published. We absolutely agree with this petition, it is every patients’ right to know about the risk and benefits of any treatment he or she undergoes. We support your claim and hope that many more will.
Guild of Healthcare Pharmacists are supporting open, transparent and full disclosure of all clinical trial data as organisationally this promotes our objective to support innovation and advancement of pharmacy practice throughout the NHS to deliver safe and effective care for our patients. The alternative could only lead to inappropriate, unsafe and uninformed choices.
British Association for Counselling and Psychotherapy endorses this campaign as an organisation that is committed to evidence based practice. BACP believes it is essential for treatment choices to be based on all available evidence and not just that which has been published.
Dietitans for Canada is pleased to sign the AllTrials petition. Like other health professions, dietitians require unrestricted access to valid and unbiased evidence when making recommendations about patient care, policy or community programs.
The Irish Hospice Foundation is committed to transparent research processes and supports both a register of trials and a mechanism to ensure all results, positive and negative, are reported. Individuals, organisations and decision-makers need access to this information. We strongly support the AllTrials initiative.
Canadian Agency for Drugs and Technologies in Health is a strong supporter of the AllTrials campaign to have all clinical trials registered and all results reported. CADTH provides decision-makers with the evidence, analysis, advice, and recommendations they require to make informed decisions in health care. These decisions should be informed by a complete evidence base which would include the disclosure of all clinical data.
Peer J is very supportive of the AllTrials initiative. Full and transparent reporting of all conducted trials is essential to the progress of research in this field.
South East Wales Trials Unit:The purpose of clinical trials is to provide the evidence for clinicians and patients as to what works and for whom. A lack of transparency in any part of the pathway for the development of interventions threatens the value of the whole body of research and leads to unacceptable bias in the management options available to patients.
Research Design and Conduct Service: We aim to support NHS researchers to produce the evidence base required for their own work – there has to be a commitment in all those undertaking trials to make them publically available in both public and the private sector.
Heamatology and Clinical Trials Unit in Cardiff is proud to support the AllTrials initiative. Having access to complete information is crucial to clinicians making properly informed judgements on treatments to offer patients, and repays the trust that trial participants have placed in us as trials organisations to ensure that their contribution to research is appropriately recognised and used for the benefit of people in the future.
British Thyroid Foundation is happy to sign up to this petition and believes it is in the interest of patients for all clinical trial data to be made available’
The Addison’s Disease Self-Help Group works to support people with adrenal failure and to promote better medical understanding of this rare condition. It aims to work with interested medical researchers in a collaborative, pragmatic and ethical manner. The ADSHG supports AllTrials for its enhancement of clinical ethics and scientific transparency.
Cardiff University is pleased to support this campaign. We strongly believe in using all available evidence, from clinical trials, to change and develop medical practice, in the spirit and the traditions of Cardiff’s first and most Illustrious clinical trialist, Sir Archie Cochrane. Clinical Trials conducted by our researchers have resulted in a number of changes to medical practice, or, in some instances, have demonstrated a lack of benefit for a new experimental treatment. We will continue to insist that all trials conducted by our own clinical researchers and Clinical Trials Units are published, and we urge all others to do the same. Cochrane would have been horrified by the notion that information, generated from patients who consented to enter a clinical trial, was being withheld, and there can be no justification, ever, for doing so.
Society for Clinical Trials: Transparency of clinical trial study design and results is important to researchers, physicians and the public. In order to design the highest quality and most ethical clinical trials in the future, we need to learn from and incorporate all past experience. The Society for Clinical Trials has signed this petition because each study participant deserves to have the data he or she contributed yield the maximum benefit to society.
Wales Cancer Trials Unit: All clinical trials should be registered and results published. All results of clinical trials have much scientific value and can shape the future of patient care. Publication of all data is necessary to progress research as quickly and safely as possible, thus producing reliable evidence to change practice, whilst minimising duplication of effort.
CONSORT: The CONSORT Group strongly supports the AllTrials campaign towards open, available data from clinical trials. The non-reporting, selective reporting and poor reporting of trials is a serious problem in medical research that can and has resulted in harm to patients. This is unacceptable and wasteful on many fronts and needs to be rectified immediately – patients deserve better.
PRISMA: The PRISMA Group is a strong supporter of the AllTrials campaign. Too often, systematic reviews are concluded with statements like “more research is needed” and “the quality of studies is too poor to make a valid assessment of effect”. Often this happens because data in primary studies are so poorly reported or entire studies are missing from the scientific record, that researchers can’t make sense of the information at hand. This problem must end and the AllTrials initiative is a fundamental part of the solution.
Figshare fully backs the AllTrials effort. The desired endpoint is completely aligned with figshare‘s ethos for open research data to make academia and medicine more efficient. The way in which clinical trial endpoints are recorded at the moment is completely unethical and has repeatedly proved detrimental to the medical community.
Hull York Medical School: Teaching in Evidence-Based Medicine is a core component of the undergraduate curriculum at HYMS – we want to ensure that future doctors know how to appriase and use evidence to inform their clinical decisions. But without access to ALL trial evidence, how can doctors be sure that those decisions are well-founded? HYMS supports the AllTrials campaign.
The Institute of Clinical Research recognises the value of making the best possible use of information gathered in clinical trials and sees facilitating appropriate meta-analyses as an important part of conducting high-quality clinical research.
Belgian Health Care Knowledge Centre: As a producer of clinical guidelines and health technology assessments, the KCE crucially depends for its work on the free availability of all relevant trial information. In matters of health, or even life or death, lack of transparency is just unacceptable. We should no longer accept that this basic right is denied to patients.
Associazione Alessandro Liberati – Network Italiano Cochrane strongly endorses the AllTrials initiative for all trials to be not just registered but also entirely published, to help patients, nurses, clinicians and policy makers make decisions based on all the best evidence. Openness is a value heavily defended by Alessandro Liberati, the founder of the Italian Cochrane Centre, and we are pleased to remember that openness contributes to strengthening the principles of democracy and respects for fundamental rights as laid down in Article 6 of the European Union treaty of Fundamental Rights of the EU.
Royal College of Physicians has agreed to support the principles of the ‘All trials registered, all trials reported’ campaign. This reflects the RCP’s commitment towards delivering greater transparency for the benefit of patient care. Greater clinical trials transparency will aid scientific progress and in turn benefit patient care. In signing up to the campaign, the RCP is keen to stress the urgency with which the community must determine how clinical trial transparency should be delivered. The full statement if available here.
Royal College of Veterinary Surgeons Charitable Trust unreservedly supports the aims of the All Trials campaign. As a funder of research and as an organisation committed to advancing veterinary knowledge, the Royal College of Veterinary Surgeons Charitable Trust strongly believes that access to (and dissemination of) the outcomes of clinical research are vital components of the process by which healthcare professionals – including veterinary surgeons – make informed choices about patient care. The full statement is available here.
Cardiff University Systematic Review Network: SysNet is please to sign the AllTrials petition. Systematic reviewers need access to all clinical data to avoid publication bias.
The Information Standard: As a certification scheme operator we at the Information Standard believe that the provision of quality, evidence based consumer health information is key to empowering individuals to make informed choices about their personal care. This activity supports this wider vision.
The German Society for Health Technology Assessment aims at supporting coverage decision-making and other decisions that are relevant for the health care system. It is essential to draw on the best available evidence. However, decision-makers and patients need to trust that decisions are based on all available evidence, not a selection that is not controlled by them. The AllTrials initiative aims at a complete evidence-base and this deserves our strong support!
European Association of Hospital Pharmacist: Hospital pharmacists are intimately involved in the conduct of clinical trials all across Europe and therefore have a strong interest in seeing transparent reporting of results become a standard reality. We are therefore pleased to join with so many other like-minded organisations in the All Trials campaign and look forward to progress being made in this area.
The Association of Democratic Pharmacists has signed this petition as we believe that access to all available clinical trial data is essential to achieve patient-oriented health care. As pharmacists we can only give informed advice to our patients if we know the whole picture. Therefore we actively promote the development of evidence based pharmacy and medicine as it is essential to improve the quality of care for patients!
The Northern California Regional Organization of Child and Adolescent Psychiatry is committed to genuine transparency in clinical research. Clinicians, and the families they serve, need and deserve sufficient access to all relevant information in order to make the best decisions possible. Nowhere can this need be more important than in the care of children, particularly those who may be dealing with mental illness. NCROCAP strongly endorses the All Trials Campaign.
The Chartered Society of Physiotherapy is the professional body for 51 000 qualified physiotherapists, physiotherapy support workers and students. The CSP strongly advocate evidence-based practice development to achieve advances in health care and public health, and are pleased to support the All Trials Campaign for the results of all clinical trials to be published.
Scottish Intercollegiate Guidelines Network: Publication bias is a crucial factor in the development of clinical guidelines. It is vitally important to be able to review the full weight of published literature when making evidence based recommendations on clinical interventions and treatments. Without a complete picture, evidence based recommendations are potentially invalid and the risk to patients is increased.
European Patients’ Forum: Since the beginning of our involvement with EU the clinical trials legislation, EPF has called for the publication of all results of all clinical trials in a timely manner, regardless of the outcomes. Ensuring that after a research project finishes, the results are promptly published is, according to our members, as important as the approval of a trial in the first place. The full statement is available here.
Test-Achats, Belgian Consumer Organisation: Public access to all data of clinical trials can prevent repetition of the drug disasters of the past. The authorities should put public health before commercial interests.
British Society of Periodontology: More research is published globally on periodontology than any of the dental sciences; periodontal diseases have both an oral and general health impact and the profession relies on high quality clinical studies to inform our understanding of these important disease processes. The British Society of Periodontology is pleased to support the AllTrials campaign to ensure transparency in trial registration and the reporting of results, to the benefit of our patients who suffer from these debilitating conditions.
PerioCourses is an independent group of dental practitioners and educators promoting the practice and understanding of periodontics amongst dental professionals. We are committed to the provision of evidence-based practice and fully endorse the aims and objectives of the AllTrials campaign to bring greater transparency to the registration and reporting of clinical research.
The German League Against Rheumatism (Deutsche Rheuma-Liga) strongly supports the All trials Initiative. As a patient organisation with over 270.00 members we plead for full disclosure of all clinical trial results. To date, we have no cure for rheumatic diseases. Only if we know about all negative as well as positive outcomes and can make treatment decisions based on the best evidence possible, we have the chance to support people with rheumatic diseases with the best medical care.
Wilson’s Disease Support Group (UK): We exist to support people with Wilson’s Disease. Patients have a right to know which treatments work reliably, and for that for that the public needs to know what is being investigated, and see all of the results.
British Dietetic Association is pleased to sign the AllTrials petition. Dietetics is an evidence based practice. It is important that all clinical trials should be reported with transparency and openness in order for patients to benefit from care designed to deliver the best possible health outcomes.
British Veterinary Association is pleased to support the All Trials campaign. Transparency and accessibility of clinical trial data for all stakeholders is as critical in veterinary medicine as in human medicine. BVA endorses the registration and full reporting of all clinical trials and believes that access to the outcomes of clinical research is vital for healthcare professionals providing evidence-based medicine and the highest quality of care.
Swedish Skeptics Association: In order to give patients the best possible treatment and to give politicians and decision makers all facts they need to make sound decisions, all results of scientific research must be made available. As an organization that is devoted to promote education about the methods of science and its results we are proud to support this urgent initiative.
The European Public Health Alliance supports the AllTrials campaign since transparency over trial registration and full access to trials outcomes will benefit not only patients, researchers and health professionals, but ultimately it will also contribute to stimulating innovation by eliminating duplication of work and wasteful use of financial resources. Access to data will allow stratified analyses by gender, age and other parameters. Clearly, making trials results publicly available is also an ethical obligation given that individuals volunteer their time and bodies for the benefit of future patients and thus they should have the right to view comprehensive results.
Scientists for Global Responsibility strongly welcomes this campaign. Openness and transparency are essential for ethical science, which SGR exists to promote. It is vital for human well-being, and indeed for the difference between life & death, that the AllTrials campaign succeeds. An extension for a similar requirement for openness and transparency needs to be applied to all research, i.e. other than just clinical trials, so as to ensure that all marketable products that are traded under the banner of science actually do what they say they do.
Children’s Liver Disease Foundation: Clinical trials are an important way for us to advance treatment but they must be carried out in an open and transparent way so that information is available to all. Only when patients have full knowledge about the treatment they are receiving can they feel empowered and, as a charity which represents the views of patients and their families, that aspect is very important to us.
Pragmatic Clinical Trials Unit: Our trials unit is fully in support of the AllTrials initiative. The registration and publication of all trials is vital to ensure better patient care, more transparent information for doctors and for the public, and more efficient future research.
World Confederation for Physical Therapy is the sole international voice for physical therapy, representing more than 350,000 physical therapists* worldwide through its 106 member organisations. WCPT is committed to furthering the physical therapy profession and improving global health through encouraging high standards of physical therapy research, education and practice. WCPT’s policy statement on research clearly advocates for the reporting of research results, both positive and negative, as an ethical responsibility and a requirement for evidence based practice. (*physical therapists are also known as physiotherapists in many countries)
Students 4 Best Evidence: As the healthcare practitioners of tomorrow, we strongly support the AllTrials campaign. Our community is firmly committed to “best evidence” and this requires full, open publication of all trial results.
National Voices is the national coalition of health and social care charities in England, with more than 150 member organisations. We work together to strengthen the voices of patients, service users, carers, their families and the voluntary organisations that work for them. We think it vital that patients have clear and accurate information about therapies: their relative efficacy, risks, harms and side-effects. The full statement is available here.
University of Lisbon School of Medicine: Medical schools train students to become doctors whose clinical practice should be based on high quality clinical evidence. Clinical trials are the gold standard to study efficacy and safety of therapeutic interventions. Since a significant percentage of clinical trials fail to detect any benefit of the interventions under study, they are published less often than studies with positive results. For the health practitioner, however, it is almost as important to know “what works” as it is “what does not work”, so the results of all clinical trials (positive or negative) should be published. In so doing, their results are available to the health community. This is why the University of Lisbon School of Medicine strongly supports the AllTrials campaign.
Center for Evidence Based Medicine, University of Lisbon: Medical practice should be based on high quality clinical evidence. Clinical trials are the gold standard for efficacy and safety of therapeutic and preventive interventions. A significant percentage of clinical trials fail to detect any benefit of the interventions under study – the so called negative studies. These tend to be published in a smaller percentage than positive studies (publication bias). For the health practitioner, however, it is almost as important to know “what works” as it is “what does not work”, so the results of all clinical trials (positive or negative) should be published, so their results should be available to the health community. This is why our Center for EBM at the University of Lisbon School of Medicine strongly supports the AllTrials campaign.
Therapeutic Guidelines Ltd: As an independent, not-for-profit organisation that develops therapeutic guidelines for the quality use of medicines, we support the AllTrials campaign because we believe the availability of the methods and results of all clinical trials is essential for evidence-based prescribing advice.
Consumers Health Forum of Australia: Although Australia has gone some way to addressing the issues surrounding the reporting and registration of clinical trails, the Consumers Health Forum of Australia (CHF) believes that this is a global problem. Around the world, up to half of all clinical trials have not been published. With the results of clinical trials being published and considered well outside national borders, it is important that unfavourable results are not withheld, and that all of the available evidence is considered when decisions are made about the efficacy of treatments. Improved transparency will benefit consumers, as well as researchers, governments and the medical community. CHF endorses the AllTrials campaign, and we call on all governments and researchers to act on this issue.
Thyroid UK is pleased to sign this petition. We has always believed that there should be more openness in regard to research and that all trials should be registered and all results reported. This would enable doctors to make an informed choice on which medications to give their patients. As patients and the public are becoming more involved in research, results should also be made available to any patients that want to see them who have been involved in the research being reported.
Pancreatic Cancer UK is pleased to sign the AllTrials petition and support work that will make all the information about clinical trials available for public scrutiny. This is important for all areas of healthcare but especially so for diseases of unmet need like pancreatic cancer. Complete openness about what trials are being run and what the results are will help patients and clinicians to make more informed choices about the treatments available to them.
BUKO Pharma-Kampagne fully supports the AllTrials campaign as access to ALL data of clinical trials is essential. Otherwise evidence-based medicine will be evidence biased medicine for ever.
Bad Science Watch advocates for good science in public policy. Government should not protect industry by putting the public at risk. We support the All Trials campaign and urge all governments to give researchers unfettered access to data that is essential for informed clinical decisions.
International Alliance of Patients’ Organizations is pleased to endorse the AllTrials campaign as an important step towards greater transparency and patient information. The full statement is available here.
Australasian College of Nutritional and Environmental Medicine is committed to evidence-based medicine truly being the gold standard in healthcare, which is why we are proud to support the AllTrials campaign to have all clinical trials registered and the results reported irrespective of whether the results are positive or negative.
Test Positive Aware Network has long recognized that only by providing all of the available information in order for people to make informed decisions about treatment and care will we ever win the fight against HIV. Pharmaceutical companies should be held to the same standard, and be entirely transparent about all trial results, both good and bad.
Plymouth University Peninsula Clinical Trials Unit believes that it is crucial for all clinical trial results to be made publicly available and disseminated appropriately in a timely fashion.
Epilepsy Action supports the All Trials campaign. It is important that our members know that we support the full publication of all clinical and research data. Transparency in all clinical trials is needed to allow prescribers to make recommendations in full knowledge of the facts. It will also allow patients to make informed choices about the potential benefits and possible side-effects of their treatments. The availability of more information will also enable independent experts to assess the effectiveness and safety of new drugs. Without this knowledge, we cannot be sure that patients are receiving the best care.
Arthritis Research UK is the leading authority on arthritis in the UK, conducting scientific and medical research into all types of arthritis and related musculoskeletal conditions. It is the UK’s fourth largest medical research charity and the only charity solely committed to funding high quality research into the cause, treatment and cure of arthritis. We welcome initiatives to increase transparency around clinical trials, including the registration of clinical trials and the publication of their results. The full statement is available here.
Pain UK: On behalf of patients who take part in clinical trials and people everywhere whose health depends on evidence-based medicine, Pain UK joins this campaign to have all trial results published.
University Hospitals Coventry and Warwickshire has signed up to AllTrials to support AllTrials’ call for all clinical trials data to be reported and ensure that all research data is more readily available in the public domain. The registration of all trials and full reporting of results irrespective of the outcome is a critical step in counteracting the bias towards positive results in the literature. This will provide better quality evidence to enable clinicians to make more informed decisions about patient care.
European AIDS Treatment Group believes that patients do a great service, willingly participating in clinical trials for the benefit of medical science and the greater good. (Sometimes of course for their own good too!) It is a travesty of justice that this data is then considered to be ‘private.’ It should be in the public arena all to see – easy to access and free for all.’
Hypermobility Syndromes Association supports the need for greater transparency in research and for all clinical trials to be registered in the public domain. Results gained from research should be available to all who wish to view them in a format which is inclusive. Patients these days are far more knowledgeable about research and how to interpret results and they should be able to do so.’
British Liver Trust fully supports the AllTrials campaign. Liver disease is the fifth biggest killer disease in the UK and is the only one of the “big5″ that continues to increase – for those at risk of or living with liver disease it is essential they have access to all clinical trial data and information. It is negligent for them not to have this!”
UK Thalassaemia Society is fully committed to transparency and accuracy in all forms of clinical or social research. It is essential that the full details of all studies, including clinical trials, are placed in the public domain in a timely fashion.
COMCEPT – The Portuguese Skeptics Community: As a volunteer-run and grass-roots organization aiming to promote rationality and critical thinking, COMCEPT – The Portuguese Skeptics Community fully supports the All Trials campaign. It is our understanding that, only with full disclosure of clinical trials data, will doctors, health professionals, and patients be able to make informed, rational, and scientifically-based decisions about health care. The disclosure of all the trials’ results will improve our true knowledge about the evidence behind each treatment and thus contribute to further advance science based medicine.
Behcets Syndrome Society: It is difficult to understand why all trials are not registered and published, to date the current situation has meant wasted effort and delays bringing new ideas and medication to patients, the evidence in support of this campaign is overwhelming.
MS Society: As an evidence based organisation, the MS Society believes that informed decisions on treatment cannot be achieved unless all trials are registered and the full methods and results reported. The full statement is available here.
European Cancer Patient Coalition supports alltrials.net petition for all clinical trials to be registered and reported regardless of their outcomes. In clinical trials, ECPC supports the registration of all trials by researchers and sponsors prior to the patient enrolment, rapid review processes, sound scientific scrutiny by researchers and clinicians and the use of open access web-based resources and methods, enabling patients and their clinicians to be informed about potential new therapies and all trials results. ECPC was established in 2003, under the slogan “Nothing About Us, Without Us” as a non-profit organization to act as an umbrella cancer patient group. Over the last ten years, ECPC has grown in size and scope, and we are now the only European organization governed by cancer patient groups.
Australian Medical Students’ Association is proud to support the AllTrials campaign. As doctors worldwide seek to provide well-informed and considered advice to their patients, it is imperative that they do so with the best evidence base available. The AllTrials campaign, and its push to require mandatory registration and reporting of all trials, is a meritorious campaign, and will only serve to strengthen the evidence available for medical students and doctors worldwide to base their diagnostic and treatment decisions.
You can read a further press release by AMSA calling for an end to the suppression of medical research data and asking all individuals and organisations that conduct research to join the AllTrials campaign.
British Association for Sexual Health and HIV strongly supports the publication of all clinical trials’ results. Without this information it is impossible for guideline producers and clinicians to make accurately informed treatment choices about efficacy and safety as the true benefits and risks of treatment cannot be determined.
Genetic Disorders UK works to improve the lives of individuals and families affected by genetic disorders. We support this important campaign so that treatment decisions can be based on all available evidence and not just that which has been published.
Primary Immunodeficiency UK is a patient led organisation supporting people with rare conditions that impair the immune system’s ability to fight infection. We strongly support the AllTrials campaign because it will help avoid duplication of effort, add to the knowledge base and better inform treatment options, so ensuring that the invaluable contribution made by people participating in clinical trials and the benefit gained, is shared fully with society.
Chronic Granulomatous Disorder Society works to help people affected by the rare, life-limiting and life-threatening condition CGD. We fully support the AllTrials campaign in the firm belief that transparency and openness in clinical trials can only lead to better outcomes for patients.
British Science Association: AllTrials is vital not just for better healthcare, but better public trust in the scientific process. The British Science Association works for better engagement between the science and the rest of society, so we’re proud to sign up to the campaign. You can read the full statement from the British Science Association here.
College of Psychiatric and Neurologic Pharmacists supports the AllTrials proposal to require universal clinical trial registration. The full statement is available here.
British Psychological Society fully supports the objectives of the campaign for all trials to be registered and all results reported. The Society strongly supports the reporting of all trial outcomes and believes the dissemination of all research results, including those of ‘null hypotheses’ and ‘non-result reporting’, promotes greater impartiality of research, research methods and the wider adoption of ethical practice and guidance.
Parkinson Society Canada is dedicated to funding Parkinson’s Disease and related disorders research. We fully support the AllTrials campaign calling for unrestricted access to the results of all research studies including clinical trials. Openness and transparency are essential in research so that patients, policy makers and health professionals can make decisions vital to health care based on sound evidence. Transparency will support and accelerate research and ultimately lead to improved treatments for patients.
Medwave strongly supports the AllTrials campaign for all trials registered and all results reported. This should also be expected from government-funded research and yet this is not the case in Latin America. Medwave is striving for public disclosure of trials, studies and reviews conducted or commissioned by government. The governments of the region should share their evidence base and efforts in order to maximize efficiency, especially in the context of tight healthcare budgets.
Cure Crohn’s Colitis: The sole purpose of Cure Crohn’s Colitis is to fund medical research into a cure for IBD – as such we couldn’t feel more strongly about the need for open, unbiased and meaningful medical research. We are 100% behind AllTrials.
The Australian Pain Management Association is a consumer organisation whose objectives include providing evidence-based information about persistent/chronic pain and promoting evidence-based policy and practice by clinicians and health systems. These objectives are undermined if all of the relevant information is not available to researchers, clinicians and consumers. Access to only selective data compromises our access and understanding of the most effective treatments and sets back the development of new and improved treatments. All clinical trials must be registered and reported, regardless of the nature of the results.
James Lind Institute: We signed the petition because we strongly support the practice of evidence based medicine. It is extremely important that our physicians and researchers have access to results of all scientific studies irrespective of the outcome in order to make the best decisions in their routine practice and in research work. Withholding negative results is in a way dishonest, has potential to cause harm to patients and can slow down the research progress.
F1000Trials aims to systematically alert clinicians to published clinical trials and communicate trials in a readily understandable way. The aims of the AllTrials campaign are therefore very important to F1000Trials. Even more importantly, we support AllTrials because, if trials are not registered or reported, ultimately clinicians and patients are making decisions about healthcare without having access to complete information on the effectiveness of treatments.
Safer Medicines Campaign strongly supports the AllTrials Campaign. We believe that all data used to support claims that a drug is safe – including preclinical animal data – should be open to full scientific scrutiny. Buried data leads to buried patients and clinical trial volunteers.
Thyroid Patient Advocacy Support (TPA) wholeheartedly supports the AllTrials campaign. It is essential that all clinical trials are registered and that methodologies and results are placed in the public domain where they are freely available to all. This will support research efforts and ultimately lead to improved clinical treatment programmes. All research data must be freely to all, so that the public can be protected from harmful side effects of drugs. Our members need access to all the relevant data, not just the information people may choose to publish.
Ministry of Health and Medical Education – Food and Drug Organization: We, in IR FDO, believe that only with availability of “all clinical trial data” evidence based decision making is possible to assure efficacy and safety of medicinal products and protect public health.
The Institute of Physics and Engineering in Medicine (IPEM) aims to advance physics and engineering applied to medicine and biology for the public good. We support the campaign for all clinical trials to be registered and made public, as part of our remit to ensure and improve the quality, safety and effectiveness of science and technology in healthcare.
NHS Blood and Transplant fully supports the AllTrials campaign. As the Special Health Authority responsible for optimising the supply of blood, tissues and organs throughout the NHS, it is vital that we have a complete and transparent evidence-base to inform our policies and practices. This cannot happen until all clinical trials are registered and their results published without exception.
Oxford Clinical Trials Research Unit (OCTRU) is committed to transparency in its research and is pleased to support the AllTrials Campaign. It is imperative that all trials should be registered and all results reported and OCTRU commits to undertake this with all of its trials.
The Health Cloud is proud to support the AllTrials campaign. Publishing all trial data will allow medical research to develop rapidly and safely, ensuring human health is protected and promoted. This is a crucial step in preventing bias in the world of public health and medicine, and we encourage all our users to support the AllTrials campaign. Full thoughts available here.
ASH Scotland is pleased to support the AllTrials campaign. As our work in public health relies greatly on the scientific and medical literature we consider transparency and openness in health research to be vital. If clinical trial data is made more available, we can all have more confidence in the outcomes of research.
Sage Bionetworks: We believe in the importance of iteratively generating and testing novel hypotheses transparently and collaboratively. Access to all trial data is critical to improve knowledge and accelerate the pace of research to improve patient care.
The European Society of Clinical Pharmacy (ESCP) strongly supports the AllTrials initiative for all trials to be entirely published. ESCP is dedicated to developing and promoting the rational and appropriate use of medicines, medical products and devices by the individual and by society. Therefore, ESCP believes that access to all available clinical trial data is essential to achieve evidence-based and patient-oriented health care.
The Guidelines-International-Network (G-I-N) is a global network with 93 organisational and 120 individual members who work to develop and implement guidelines to support evidence-based health care and improved health outcomes throughout the world. G-I-N believes that the availability of the results of all clinical trials is essential for guideline developers to make informed recommendations about the appropriate use of therapeutic interventions in routine clinical practice.
The Royal Institution is proud to back the AllTrials campaign. The Ri has been encouraging people to think further about science and its applications for over 200 years and we remain true to our founding principle of promoting “The speedy and general diffusion of the knowledge of all new and useful improvements in whatever quarter of the world they may originate”. Encouraging people to participate in informed discussions about science is just as important today and so we fully support the AllTrials call for greater transparency around clinical trials. We believe it is vital to open up the world of science and technology, thus providing a platform for the public not just to gain access to credible information, but to genuinely involve them in discovery, innovation and discussions about our collective future.
The Welsh Intensive Care Society supports the All Trials Campaign. Without access to the results of all clinical trials, it is impossible to say that treatment decisions are based on the best available evidence. It is more important than ever that the treatments we give to our patients are based on such evidence. We simply cannot afford to give sub-optimal or ineffective therapies any longer – this is not only financially wasteful but may put patients at risk of harm.
The Institute for Evidence Based Medicine College of Medicine (Korea University) supports AllTrials because we believe opening the results of all clinical trials will do benefit to the public around the world.
The European Federation of the Associations of Dietitians (EFAD) supports the AllTrials campaign for all clinical trials to be registered and all results to be reported. EFAD believes that good nutrition plays an important role in society, both in maintaining health and aiding recovery from disease. EFAD also advocates for all dietetic practice to be evidence based. This is only possible if all the evidence from all the trials is available to dietitians and policy makers. Without access to all the evidence dietitians cannot offer the best dietary advice to improve both individuals’ and the population’s health or make informed decisions about which health policies to promote.
The German Association of Hospital Pharmacists (ADKA) supports the AllTrials initiative to broaden the knowledge available on pharmacotherapy. This would advance the objective recommendation of treatment strategies as well as the support of treatment decisions and therefore, ameliorate patient safety and outcomes.
The European Prostate Cancer Coalition (Europa UOMO) strongly supports the All Clinical Trials Registered Campaign. Europa UOMO is the European Prostate Cancer Patient Support Organization representing national member associations from 22 states. Clinical trials provide innovations and evidence about the properties of medical methods and materials. Public funds, structures and contributions from charities often support clinical trials. Physicians and patients need access to all trials in order to make the best possible therapy decisions and insure that patients are not exposed to unnecessary risk that the wrong treatment may be prescribed.
The Ear Foundation is pleased to support the AllTrials Campaign both in the UK and worldwide. Service users are at the heart of everything that we do at The Ear Foundation and our research, along with other clinical research, is vital to ensure that people have access to the most up to date and accurate information.
European Journal of Hospital Pharmacy: Clinical trials data is essential to the pharmacists role in making decisions about best healthcare. Access to all data is key to good decision making and in the best interests of patients, carers and clinicians.
Plymouth Community Healthcare is a social enterprise providing integrated healthcare services to a varied population. We aspire to be an employee led organisation and our staff have approached the board to request that we support the AllTrials campaign. We are delighted to agree to this as AllTrials represents a positive step towards getting all clinical research published and make the evidence base behind our clinical practice much more transparent.
The Dupuytren Foundation enthusiastically supports the AllTrials campaign. There must be both transparency and data access to make real progress in developing better understanding and more effective treatment for Dupuytren disease.
PharmaXL is happy to support the AllTrials campaign. We believe that total transparency in research will open possibilities for investigators to create more partnerships. Additionally, transparency is required for the pharmaceutical industry to regain their credibility. And last, but certainly not least, total transparency will benefit not only the individual patient, but the society as a whole.
The PHG Foundation is a think-tank with the mission making science work for health. Identifying the best technologies and treatments for health requires a robust and transparent evidence base, and we strongly support registration of all clinical trials and subsequent release of data to underpin decision-making.
Association of the Scientific Medical Societies in Germany (AWMF) is an umbrella organization of 168 scientific societies from all fields of medicine. AWMF signs the AllTrials petition because all scientists need to see all results of studies and trials having been started – positive results as well as negative results – to get the best available evidence for recommendations and guidelines for doctors and patients.
The UKCRC Registered Clinical Trials Units have always required all of their trials to be registered and published. We are delighted to sign this petition so as to raise the standard of clinical trials more widely. We are concerned, however, that any regulatory or governance requirements that codify these principles should be drafted with great care and consulted on widely to prevent any unintended adverse consequences.
The TREAT-NMD Alliance supports the campaign to ensure transparency and disclosure of data from all clinical studies in an attempt to better educate the community and bring forward well-designed trials that better serve the limited patient populations affected with these rare diseases.
The Swiss Skeptics (“Skeptiker Schweiz – Verein für kritisches Denken”) would very much like to support the AllTrials campaign. Transparency in clinical trial results is not only an essential step towards improving the validity and reliability of clinical research. This kind of reform can also help alleviate the growing public distrust of science: When we show that science as it is practiced can be improved, we can reduce the dismissive, hostile attitude towards science that is becoming ever more common.
The British HIV Association strongly supports the AllTrials campaign. Valid and reliable guidelines are critically dependent on analysis of data from all relevant clinical trials. Without this people are at risk of harm; either from adverse effects of treatment or the opportunity costs of ineffective treatment.
American Board of Sport Psychology Too often subsidized agenda-driven positive outcome research gets published, makes headlines and impacts funding, practice and policy decisions, frequently, despite the fact that derived data may be questionable. By contrast, there is a long history of negative findings being discarded, never to see the light of day. All clinical trial and all research data for that matter should be accessible for scrutiny and re-analysis and importantly, negative findings must be made known irrespective of vested interests whose main concern is to monetize positive research findings. We support the AllTrials initiative in the interest of transparency and highest research ethics.
Irish Medical Organisation supports the Alltrials movement and calls for the mandatory publishing of all clinical trial data. This should be a requirement in the application process for ethical approval for clinical trials.
Torheim Pharmaceuticals AS: AllTrials is an important initiative to make use of ALL available knowledge about the drugs we give our patients. Medical advances built on flawed or incomplete information may turn out not be advances at all.
The King’s Clinical Trials Unit at King’s Health Partners strongly supports the AllTrials initiative and is working to ensure that all trials supported by our unit, historical and ongoing, are published. We would like to encourage other UKCRC registered Clinical Trials Units to sign up to AllTrials and to make every effort to publish their trials or make available their datasets, as we are well positioned to make a real difference.
Associazione Salute Attiva Onlus is an italian non-profit association and we support the citizen empowerment on health issues. We support the Alltrials campaign as it is a very important issue which every person should be informed about.
The Cambridge Clinical Trials Unit recognises the value of evidence based medicine and is committed to transparency regarding all trial outcomes. We support the dissemination and publication of all research findings, whether “positive” or “negative”, to allow full appraisal of all conducted trials.
The Chartered Institute of Library and Information Professionals supports, as a matter of principle, measures to improve people’s access to information. Many of our members have been leaders in advocating and implementing open access models, recognising the huge public benefits that come from the wider dissemination of research outputs. This initiative is an important part in helping to deliver the evidence-based healthcare that our members working in library and knowledge services in the UK healthcare system promote and support on a daily basis.
The Global Health Network strongly supports the AllTrials initiative as we believe that this will significantly contribute to better health outcomes globally. We support openness and transparency in health research.
The German Public Health Association supports the initiative because the complete reporting of all trials is essential for public health.
Advertising Health: Making trial data available makes perfect sense and can only improve patient outcomes, something that most healthcare advertising agencies care about more than anything. We will be encouraging the rest of our subscribers to follow the other agencies that have already signed the petition.
INC-ARGENTINA: The National Cancer Institute from Argentina strongly supports the idea that transparency makes better science and better health. Medical research potentially affects all human beings and for that reason its results should be reported openly and comprehensively to improve of people’s life.
The German Society for Wound Healing and Wound Treatment (DGfW) is a scientific medical society aimed at providing patient-oriented and evidence-based wound therapy and care. We are also engaged in clinical practice guidelines and education which are both grounded on transparency. We therefore support the AllTrials Campaign since transparency in research and access to evidence is essential for making well-informed clinical decisions.
College of Optometrists: Recently developed treatments mean the NHS can now treat eye diseases that would previously have left hundreds of thousands of people visually impaired. Having access to all trial data will enable us to save the sight of even more people in the years to come.
MRSA Action UK believe that all clinical trial findings should be made available so that those with responsibility for developing guidance and making treatment decisions have all the necessary information to hand to help them do so safely and effectively. Information should also be published in an easy to understand format so that patients and carers can help make informed choices about their care.
Joining Jack are pleased to support AllTrials petition for all clinical trials to be registered and their results to be published. We encourage the movement of potential new treatments into the clinic as quickly and as safely as possible, and greater transparency in clinical trials will speed up the current drug approval process. It will enable patients affected by Duchenne to have faster access to crucial new treatments.