Brexit vote spurs UK review of clinical trial guidelines

In the context of Britain’s recent decision to leave the EU, the UK Medicines and Healthcare products Regulatory Agency (MHRA) has invited any interested parties to provide feedback on their new clinical trial guidance documents by the end of August 2016. According to the call:
The UK is assessing the potential impact on our regulatory framework […]

3rd August 2016|

National Comprehensive Cancer Network® joins AllTrials campaign for clinical trial transparency

The National Comprehensive Cancer Network® (NCCN®) has joined 668 other patient advocacy groups, professional societies, academic institutions, medical organizations, and thousands of patients worldwide in supporting the global campaign for clinical trial registration and reporting. 

NCCN®’s spokesperson, Lisa Lentz, Director of Policy and Quality, said:
“The National Comprehensive Cancer Network® supports the AllTrials campaign and its goal of clinical trial […]

13th July 2016|

Publishers announce new way to link clinical trials with publications

A group of publishers today announced a development that will allow clinical trials to be easily linked to related publications, such as the study protocol, statistical analysis plan, and articles reporting trial results. The system will link items using clinical trial numbers (CTNs) and digital object identifiers (DOIs). Publishers will also be able to highlight […]

17th May 2016|

The US version of the AllTrials video is now live!

Our friends in the US have just launched a new AllTrials video. Please share it far and wide.

The US version of the original AllTrials video features two passionate American patient advocates, AnneMarie Ciccarella and Gregg Gonsalves explaining exactly why the campaign for clinical trial transparency matters to them and other patients in the US.

Thanks to your support, we were […]

31st March 2016|

American Medical Association joins AllTrials

Today the American Medical Association (AMA) joins more than 641 patient advocacy groups, professional societies, medical organisations and thousands of patients worldwide in supporting the global campaign for clinical trial registration and reporting led by AllTrials.

AMA President, Steven J. Stack, said:
“The AMA strongly supports improving the timeliness and accessibility of clinical trial data to reduce the duplication of research […]

17th March 2016|

Lessons need to be learned from clinical trial tragedy

The British Journal of Clinical Pharmacology has published an editorial calling for improvements to the safety of clinical trials, following the tragic outcomes of the Bial clinical trial in January 2016, when five volunteers were hospitalised and one subsequently died.

The authors make several recommendations for learning from this tragedy, which include:

Pre-clinical and clinical study data from […]

16th March 2016|

Favourable results have more scientific impact than unfavourable results

A study published in JAMA Oncology has revealed that ‘positive’ cancer clinical trial results have a much higher scientific impact than ‘negative’ results.

A total of 94 patient studies were looked at, containing data from 46,424 trial participants. Out of these, only 28% of trials showed positive results. However, these trials were far more likely to be published in high impact journals than negative trials. […]

14th March 2016|

How institutions can audit registration and publication of clinical trials

In a world first, a clinical trial transparency audit of two major UK research institutions has been made publicly available. The study, published in BMJ Open, looked at the clinical trial registration and reporting performance of the Oxford Biomedical Research Centre (BRC), and the Oxford Musculoskeletal Biomedical Research Unit (BRU), who together received over £160m of public funds […]

9th March 2016|

Will the EMA’s guidance usher in a new era of trial transparency?

The European Medicines Agency (EMA) has published new guidance for pharmaceutical companies on how to comply with its policy on the publication of clinical data. The guidelines address how to prepare and submit clinical study reports (CSRs), including how to anonymise data, and how to identify and redact commercially confidential information.

CSRs are very long documents that contain detailed information about […]

9th March 2016|

Sense about Science is recruiting an AllTrials campaign manager

Campaigns manager

Sense about Science is an independent campaigning charity that monitors and challenges the misrepresentation of science and scientific evidence in public life. We advocate for openness and honesty about scientific claims and findings, and mobilise the public to ask questions about science and evidence.

We are recruiting for this post to run the AllTrials campaign […]

2nd March 2016|