Síle Lane and Ben Goldacre gave evidence to the House of Commons Science and Technology Committee’s inquiry into research integrity along with Dr Simon Kolstoe.
Watch the session:
Publication bias in clinical trials is the most thoroughly researched aspect of research integrity – having been discussed in detail for over 30 years. And now the area with quite […]
Our review of the world’s largest pharmaceutical companies’ trial registration and reporting policies is now published in the BMJ. This is the first time anyone has systematically examined and compared published company policies on trial transparency.
We found:
Most of the largest companies, though not all, have some sort of publicly stated policy about registering and reporting results from current […]
Some of the world’s largest research funders and NGOs today agreed to adopt the WHO’s strong standards on clinical trial transparency. This means all clinical trials they fund or support will be registered and the results reported.
In a joint statement, nine major funders including Médecins Sans Frontières, the Bill & Melinda Gates Foundation, the Indian Council of Medical […]
Canadians: now is our best chance to get Health Canada to take a big step towards making results from all clinical trials available.
Back in 2014, the Canadian government passed the Protecting Canadians from Unsafe Drugs Act, commonly known as Vanessa’s Law. Following pressure from AllTrials, the law gave the Minister of Health the authority to […]
Este documento tiene el propósito de presentar las iniciativas de la campaña que ya están en marcha y de sugerir aquello que pueden hacer las organizaciones para cambiar las cosas en su sector. Está diseñado para mostrar de forma clara y sencilla lo que pueden hacer los irmantes de la campaña para generar la mayor […]
The latest issue of the Advanced Emergency Nursing Journal includes an editorial on the importance of clinical trial transparency.
Evidence-based practice has become an expectation in health care. In recent years, the retraction of studies based on scientific fraud and outright fabrication of data has been highly publicized in both popular and scientific literature. Although the […]
AARP (formally the American Association of Retired Persons) joins AllTrials. With close to 38 million members, this is a fantastic addition to the global call for clinical trial transparency.
AARP recognizes the importance of clinical trial transparency and supports the AllTrials campaign, which calls for the registration of all clinical trials and the publication of their […]
In early October 2016, JAMA Internal Medicine published a paper indicating that less than half of failed Phase III clinical trials are subsequently published in peer-reviewed journals. The authors warned that the widespread failure to publish such failed trials hinders medical progress, wastes resources, and places patients in harm’s way.
The paper examined the development process […]
A systematic review published in September 2016 indicted that adverse events reporting in academic journals may be improving. The review, which examined 368 journal articles about clinical trials that tested spinal manipulative therapy interventions, found that only 38% of all articles reported on adverse events, but that the rate among articles published since 2010 was […]
A study published in September 2016 found major discrepancies in the reporting of clinical trials involving children. A team of researchers examined 20 trials and discovered that “all 20 trials selectively reported or failed to report main outcomes”.
In addition, the researchers found:
13 trials completed early without justification
11 downgraded or modified primary outcome or upgraded secondary […]