This is an article published by Wiley Exchanges on 10th December. You can read the full piece here.

The best available evidence suggests that between a third and a half of all clinical trials conducted have not gone on to be published. Worse than that, trials with positive results are about twice as likely to be published as those with negative results. This means that when systematic reviews are conducted, analyzing all the available evidence on a particular topic, they often draw conclusions which do not reflect reality. So researchers, regulators, and doctors see a distorted picture and can’t make truly informed decisions about what treatments are best for patients.

Continue reading this article here.