BioMed Central: Publication bias is a serious problem in medical research and increasing transparency in clinical trials reporting is important. Open access publishing and public registration of trials offer the tools to help improve the reliability of medical evidence. All BioMed Central’s medical journals require prospective registration of clinical trials as a condition of publication, and we operate the ISRCTN register, one of the world’s largest trial registration databases. Many of our journals, including Trials journal, actively encourage the publishing of all research results, positive and negative, in addition to trial protocols. The AllTrials campaign comes at a time when there is much needed attention on the problems of reliability in medical research and we are looking forward to working with the campaign and like-minded organizations to leverage this momentum for the benefit of science and, ultimately, patient care.