eLife enthusiastically supports AllTrials’ call for all clinical trials to be registered and reported. The last decade has seen a revolution in open-access publishing of scientific articles to audiences as wide as possible. eLife is dedicated to advancing scientific excellence and also access to the best science. In this spirit, AllTrials’ efforts to ensure full reporting of clinical trials are consistent with the goals of eLife. Rapid review processes, fair scientific scrutiny by scientists and the use of additional web-based materials and open-access methods ensures that eLife is well placed to meet AllTrials related objective of fast and fair publication of key clinical trial results. We therefore welcome AllTrials and call on other journals to support this important new initiative.