German Institute for Quality and Efficiency in Health Care: IQWiG supports the campaign for all trials to be registered and the full methods and the results to be reported. IQWiG prepares health technology assessments to support decision making in the German health care system. During the past years we have experienced that full availability of all clinical trials and all information on methods and results of these trials is essential for us to provide unbiased and meaningful assessments. Health technology assessment should be based on a full evidence base and thus requires registration and reporting of all trials, regardless of whether they are conducted by industry, academia, governmental organisations or others.